3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

Base Information

Chemical Name:3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol
CAS No.:114351-45-0
Molecular Formula:C₂₁H₁₂F₃N₃O₂S
Molecular Weight:427.406
Hs Code.:

Synonyms:3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

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Chemical Property of 3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

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Technology Process of 3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

There total 5 articles about 3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 114351-34-7
2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

: 114351-45-0
3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

Guidance literature:: With dmap; In tetrahydrofuran; for 16h; Heating;
DOI:10.1021/jm00402a034

Reference yield:

: 4755-72-0,39266-56-3
Chloro-phenyl-acetic acid

: 114351-45-0
3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine, isobutyl chloroformate / CH₂Cl₂ / 0.5 h / -20 °C

2: 75 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

3: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

4: 100 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Heating

With 4-methyl-morpholine; dmap; n-butyllithium; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00402a034

Reference yield:

: 313-12-2
2-amino-3-(trifluoromethyl)benzoic acid

: 114351-45-0
3-Phenyl-1-[(Z)-thiazol-2-ylimino]-5-trifluoromethyl-1,3-dihydro-furo[3,4-b]quinolin-9-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

3: 100 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Heating

With 4-methyl-morpholine; dmap; n-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00402a034