2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Base Information

Chemical Name:2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide
CAS No.:114351-34-7
Molecular Formula:C₂₁H₁₅ClF₃N₃O₃S
Molecular Weight:481.883
Hs Code.:

Synonyms:2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Suppliers and Price of 2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

There total 5 articles about 2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2719-23-5
2-acetamidothiazole

: 2-chlorobenzyl-8-trifluoromethyl-4H-1,3-benzoxazin-4-one

: 114351-34-7
2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 4755-72-0,39266-56-3
Chloro-phenyl-acetic acid

: 114351-34-7
2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine, isobutyl chloroformate / CH₂Cl₂ / 0.5 h / -20 °C

2: 75 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

3: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jm00402a034

Reference yield:

: 313-12-2
2-amino-3-(trifluoromethyl)benzoic acid

: 114351-34-7
2-(2-chloro-2-phenylacetamido)-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; In dichloromethane;
DOI:10.1021/jm00402a034