5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine
CAS No.:157770-10-0
Molecular Formula:C₃₆H₄₃FN₂O₈Si
Molecular Weight:678.83
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 157770-09-7
5’-O-4,4'-dimethoxytrityl-5-fluorouridine

: 157770-11-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-5-fluorouridine

: 157770-10-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

: 5'-O-(4,4'-dimethoxytrityl)-2',3'-O-bis(tert-butyldimethylsilyl)-5-fluorouridine

Guidance literature:: With pyridine; 1H-imidazole; for 5h; Ambient temperature;
DOI:10.1021/jo00098a044

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 157770-10-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / Ambient temperature

2: 20 percent / pyridine, imidazole / 5 h / Ambient temperature

With pyridine; 1H-imidazole;
DOI:10.1021/jo00098a044

Reference yield:

: 316-46-1
5-fluorouridine

: 157770-10-0
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / Ambient temperature

2: 20 percent / pyridine, imidazole / 5 h / Ambient temperature

With pyridine; 1H-imidazole;
DOI:10.1021/jo00098a044