phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Base Information

Chemical Name:phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate
CAS No.:1422361-41-8
Molecular Formula:C₂₄H₂₀Cl₂F₂N₂O₅
Molecular Weight:525.336
Hs Code.:

Synonyms:phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

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Chemical Property of phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

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Technology Process of phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

There total 8 articles about phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.52%

: 1422361-41-8
phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide;

Reference yield: 76.9%

: 1422361-76-9
5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy) phenoxy]pentanoic acid

: 108-95-2,27073-41-2
phenol

: 1422361-41-8
phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 15 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 151103-08-1
4-difluoromethoxy-3-hydroxybenzaldehyde

: 1422361-41-8
phenyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

2.1: sodium chlorite; aminosulfonic acid; acetic acid / water / 0.5 h / 5 - 10 °C

3.1: thionyl chloride / toluene / 1.5 h / 90 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 10 °C / Inert atmosphere

5.1: lithium hydroxide / methanol / 1.33 h / 60 °C

5.2: pH 4

6.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 2.5 h / 15 °C / Inert atmosphere

With dmap; sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; mineral oil;