propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Base Information

Chemical Name:propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate
CAS No.:1422361-40-7
Molecular Formula:C₂₁H₂₂Cl₂F₂N₂O₅
Molecular Weight:491.319
Hs Code.:

Synonyms:propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Chemical Property:

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Technology Process of propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

There total 4 articles about propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22889-78-7
3,5-dichloro-4-aminopyridine

: C₁₆H₁₉ClF₂O₅

: 1422361-40-7
propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 10 ℃; for 1h; Inert atmosphere;

Reference yield:

: 151103-08-1
4-difluoromethoxy-3-hydroxybenzaldehyde

: 1422361-40-7
propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

2: sodium chlorite; aminosulfonic acid; acetic acid / water / 0.5 h / 5 - 10 °C

3: thionyl chloride / toluene / 1.5 h / 90 °C / Inert atmosphere

4: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 10 °C / Inert atmosphere

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; water; toluene; acetonitrile; mineral oil;

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1422361-40-7
propyl 5-[5-{[(3,5-dichloropyridin-4-yl)amino]carbonyl}-2-(difluoromethoxy)phenoxy]pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water; N,N-dimethyl-formamide / 2 h / 120 °C

2: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

3: sodium chlorite; aminosulfonic acid; acetic acid / water / 0.5 h / 5 - 10 °C

4: thionyl chloride / toluene / 1.5 h / 90 °C / Inert atmosphere

5: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 10 °C / Inert atmosphere

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;