benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

Base Information

Chemical Name:benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate
CAS No.:150544-85-7
Molecular Formula:C₂₇H₃₆N₂O₆S
Molecular Weight:516.659
Hs Code.:

benzyl (2RS)-2-benzyl-3-<<N-<4-<(tert-butyloxycarbonyl)amino>piperidinyl>>sulfonyl>propionate

Synonyms:benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

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Technology Process of benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

There total 1 articles about benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 128117-17-9
2-Benzyloxycarbonyl-3-phenyl-1-propylsulfonyl Chloride

: 150544-85-7
benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃; for 0.25h;
DOI:10.1021/jm00071a009

Reference yield: 61.9%

: 150544-85-7
benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

: 135632-49-4
(2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 760 Torr;
DOI:10.1021/jm00071a009

Reference yield:

: 150544-85-7
benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

: (2S,3R,4S)-N-(N-{(2R)-3-[(4-aminopiperidyl)sulfonyl]-2-benzylpropionyl}-L-histidyl)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 61.9 percent / H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

2: 38.7 percent / HOBt*H₂O, HBTU, N-ethylmorpholine / dimethylformamide / 24 h / Ambient temperature

3: 92.6 percent / thiophenol / acetonitrile / 2 h / Ambient temperature

4: 85.9 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

With N-ethylmorpholine;; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; thiophenol; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00071a009