128117-17-9

Upstream product

• 2495-35-4 benzylacrylate 
• 507-09-5 tiolacetic acid 
• 136010-55-4 benzyl (2RS)-2-benzyl-3-(acetylthio)propionate 

Downstream Products

• 150544-85-7 benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate 
• 135632-48-3 [1-((S)-2-{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-3-phenyl-propane-1-sulfonyl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 135650-75-8 (1-{(S)-2-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-3-phenyl-propane-1-sulfonyl}-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 135632-49-4 (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid 

Relevant academic research and scientific papers

Inhibitors of retroviral proteases

The present invention relates to compounds of the formula I STR1 wherein A, Y, R2, R3, R4, R5, R6, l, m and the corresponding radicals labeled with * are defined as stated in the description, a process for their preparation and their use for the inhibition of retroviral proteases.

Renin inhibitors containing a pyridyl amino diol derived C-terminus

Based on the concept of transition-state analogs, a series of nonpeptide renin inhibitors with the new (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy- 6-(2-pyridyl)hexane moiety at the C-terminal functionality were synthesized and evaluated for inhibition

PEPTIDYL AMINODIOL RENIN INHIBITORS

A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.

Renin-inhibiting functionalized peptidyl aminodiols and - triols

A renin inhibiting compound of the formula: or a pharmaceutically acceptable salt, ester or prodrug thereof.