diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

Base Information

Chemical Name:diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate
CAS No.:144514-40-9
Molecular Formula:C₂₀H₂₆ClN₃O₅S
Molecular Weight:455.963
Hs Code.:

Synonyms:diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

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Chemical Property of diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

Chemical Property:

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Technology Process of diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

There total 4 articles about diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150557-82-7
1-(4-(2-chlorophenyl)piperazin-1-yl)ethan-1-one

: 144514-40-9
diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

Guidance literature:: Multi-step reaction with 4 steps

1: 62.5 percent / H₂SO₄, HNO₃ / 2.5 h / 15 °C

2: 83 percent / H₂ / 10percent Pd-C / ethanol

3: 66 percent / triethylamine / CHCl₃ / Ambient temperature

4: 1.) NaH / 1.) THF, 2.) THF, r.t.

With sulfuric acid; hydrogen; nitric acid; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; chloroform;
DOI:10.1021/jm00103a011

Reference yield:

: 144514-36-3
1-acetyl-4-(2-chloro-5-nitrophenyl)piperazine

: 144514-40-9
diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / H₂ / 10percent Pd-C / ethanol

2: 66 percent / triethylamine / CHCl₃ / Ambient temperature

3: 1.) NaH / 1.) THF, 2.) THF, r.t.

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; chloroform;
DOI:10.1021/jm00103a011

Reference yield:

: 144514-38-5
3-(4-acetyl-1-piperazinyl)-4-chloroaniline

: 144514-40-9
diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / triethylamine / CHCl₃ / Ambient temperature

2: 1.) NaH / 1.) THF, 2.) THF, r.t.

With sodium hydride; triethylamine; In chloroform;
DOI:10.1021/jm00103a011