tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

Base Information

Chemical Name:tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate
CAS No.:870447-62-4
Molecular Formula:C₂₇H₃₁F₃N₄O₆
Molecular Weight:564.562
Hs Code.:

Synonyms:tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

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Chemical Property of tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

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Technology Process of tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

There total 4 articles about tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 415684-05-8
tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate

: 870447-60-2
1-(benzyloxycarbonyl)-4-[4-(benzyloxycarbonyl)amino-2,3,6-trifluorophenyl]piperazine

: 870447-62-4
tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

Guidance literature:: 1-(benzyloxycarbonyl)-4-[4-(benzyloxycarbonyl)amino-2,3,6-trifluorophenyl]piperazine; With lithium tert-butoxide; In DMF (N,N-dimethyl-formamide); hexane; at 0 ℃;

tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate; In DMF (N,N-dimethyl-formamide); hexane; at 0 - 20 ℃;

Reference yield:

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 870447-62-4
tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

2.1: ethanol; water; tin(ll) chloride / 2 h / Heating / reflux

2.2: 13 h / 0 - 20 °C / pH 10

3.1: sodium hydroxide / tetrahydrofuran; water / 24 h / 0 - 20 °C

4.1: lithium tert-butoxide / DMF (N,N-dimethyl-formamide); hexane / 0 °C

4.2: 0 - 20 °C

With sodium hydroxide; ethanol; water; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; lithium tert-butoxide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane; water; dimethyl sulfoxide;

Reference yield:

: 870447-61-3
C₁₈H₁₈F₃N₃O₂

: 870447-62-4
tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 24 h / 0 - 20 °C

2.1: lithium tert-butoxide / DMF (N,N-dimethyl-formamide); hexane / 0 °C

2.2: 0 - 20 °C

With sodium hydroxide; lithium tert-butoxide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane; water;