(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

Base Information

Chemical Name:(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide
CAS No.:1369768-75-1
Molecular Formula:C₁₇H₁₉N₃O₂
Molecular Weight:297.357
Hs Code.:

Synonyms:(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

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Chemical Property of (1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

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Technology Process of (1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

There total 12 articles about (1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369767-18-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

: 1369768-75-1
(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 168h;

Reference yield:

: 1369769-28-7
C₁₇H₁₇ClN₂O₂

: 1369768-75-1
(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

Guidance literature:: With ammonia; In tetrahydrofuran; water; at 0 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.5b00217

Reference yield:

: 1369767-15-6
((1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-phenylcyclopropyl)methanol

: 1369768-75-1
(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1 h / -60 - 20 °C

1.2: 14 h / 20 °C

2.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 168 h / 20 °C

With oxalyl dichloride; ammonium chloride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1.1: |Swern Oxidation;
DOI:10.1021/jm400772t