[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

Base Information

Chemical Name:[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid
CAS No.:1245623-66-8
Molecular Formula:C₁₃H₁₁ClF₃N₃O₃
Molecular Weight:349.697
Hs Code.:

Synonyms:[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

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Chemical Property of [3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

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Technology Process of [3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

There total 9 articles about [3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1245622-75-6
{3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 1245623-66-8
[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In methanol; under 760.051 Torr;

Reference yield:

: 1245622-74-5
methyl {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

: 1245623-66-8
[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 1 h / 20 °C

2: hydrogen / 5%-palladium/activated carbon / methanol / 760.05 Torr

With water; hydrogen; lithium hydroxide; 5%-palladium/activated carbon; In methanol;

Reference yield:

: 1228650-25-6
5-(4-chlorophenyl)-4-[⁽²⁸⁾-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1245623-66-8
[3-(4-Chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

2: chiral selector poly(N-methacryloyl-L-isoleucine-3-pentylamide)-based silica gel column / ethyl acetate; 2-Methylpentane / 24 °C / Resolution of racemate

3: dmap; trifluoromethylsulfonic anhydride; pyridine / acetonitrile / 12 h / 20 °C

4: water; lithium hydroxide / methanol / 1 h / 20 °C

5: hydrogen / 5%-palladium/activated carbon / methanol / 760.05 Torr

With pyridine; dmap; trifluoromethylsulfonic anhydride; water; hydrogen; potassium carbonate; potassium iodide; lithium hydroxide; 5%-palladium/activated carbon; In methanol; 2-Methylpentane; ethyl acetate; acetonitrile;