(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

Base Information

Chemical Name:(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene
CAS No.:937183-73-8
Molecular Formula:C₁₉H₂₁BrFNO₄
Molecular Weight:426.282
Hs Code.:

Synonyms:(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

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Chemical Property of (E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

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Technology Process of (E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

There total 7 articles about (E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 937183-69-2
(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

: 937183-73-8
(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

Guidance literature:: With potassium carbonate; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm070025+

Reference yield:

: 13466-43-8
3-bromo-pyridin-2-ol

: 937183-73-8
(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / N-iodosuccinimide / acetonitrile / 1 h / Heating

2: 75 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3: 77 percent / K₂CO₃; tetrabutylammonium bromide / Pd(OAc)2 / dimethylformamide / 2 h / 65 °C

4: 97 percent / K₂CO₃ / ethanol; tetrahydrofuran / 2 h / 20 °C

With N-iodo-succinimide; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; 2: Mitsunobu reaction / 3: Heck reaction;
DOI:10.1021/jm070025+

Reference yield:

: 937183-64-7
3-bromo-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridine

: 937183-73-8
(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / K₂CO₃; tetrabutylammonium bromide / Pd(OAc)2 / dimethylformamide / 2 h / 65 °C

2: 97 percent / K₂CO₃ / ethanol; tetrahydrofuran / 2 h / 20 °C

With tetrabutylammomium bromide; potassium carbonate; palladium diacetate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1021/jm070025+