(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

Base Information

Chemical Name:(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate
CAS No.:937183-69-2
Molecular Formula:C₂₁H₂₃BrFNO₅
Molecular Weight:468.32
Hs Code.:

Synonyms:(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

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Technology Process of (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

There total 6 articles about (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 937183-69-2
(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

Guidance literature:

Reference yield:

: 13466-43-8
3-bromo-pyridin-2-ol

: 937183-69-2
(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / N-iodosuccinimide / acetonitrile / 1 h / Heating

2: 75 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3: 77 percent / K₂CO₃; tetrabutylammonium bromide / Pd(OAc)2 / dimethylformamide / 2 h / 65 °C

With N-iodo-succinimide; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2: Mitsunobu reaction / 3: Heck reaction;
DOI:10.1021/jm070025+

Reference yield:

: 373-45-5
2-(2-(2-fluoroethoxy)ethoxy)ethanol

: 937183-69-2
(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

2: 77 percent / K₂CO₃; tetrabutylammonium bromide / Pd(OAc)2 / dimethylformamide / 2 h / 65 °C

With di-isopropyl azodicarboxylate; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Mitsunobu reaction / 2: Heck reaction;
DOI:10.1021/jm070025+