2-[2-(2-Fluoroethoxy)ethoxy]ethanol

Base Information

• Chemical Name: 2-[2-(2-Fluoroethoxy)ethoxy]ethanol
• CAS No.: 373-45-5
• Molecular Formula: C6H13FO3
• Molecular Weight: 152.166
• Hs Code.: 2909499000
• European Community (EC) Number: 822-258-0
• UNII: QQF9TLC879
• DSSTox Substance ID: DTXSID80190756
• Nikkaji Number: J34.784A
• Wikidata: Q83063160
• Mol file: 373-45-5.mol

Synonyms:2-[2-(2-fluoroethoxy)ethoxy]ethanol;373-45-5;2-(2-(2-fluoroethoxy)ethoxy)ethanol;BRN 1699131;QQF9TLC879;ETHANOL, 2-(2'-(2''-FLUOROETHOXY)ETHOXY)-;2-(2'-(2''-Fluoroethoxy)ethoxy)ethanol;Ethanol, 2-[2-(2-fluoroethoxy)ethoxy]-;C6H13FO3;2-Fluoro-2'-(2''-hydroxyethoxy)diethyl ether;3-01-00-02098 (Beilstein Handbook Reference);2-(2-(2-Fluoroethoxy)ethoxy)ethan-1-ol;2-[2-(2-fluoroethoxy)ethoxy]ethan-1-ol;ETHANOL, 2-(2-(2-FLUOROETHOXY)ETHOXY)-;UNII-QQF9TLC879;SCHEMBL2373680;DTXSID80190756;C6-H13-F-O3;MFCD01727881;AKOS024257132;LS-66794;CS-0112644;EN300-298690;A903162;Z1618124684

Chemical Property of 2-[2-(2-Fluoroethoxy)ethoxy]ethanol

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Boiling Point: 221.6°Cat760mmHg
• Flash Point: 110°C
• PSA: 38.69000
• Density: 1.062g/cm³
• LogP: -0.01860
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 152.08487243
• Heavy Atom Count: 10
• Complexity: 61

Purity/Quality:

97% ^*data from raw suppliers

2-[2-(2-Fluoroethoxy)ethoxy]ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCF)O

Technology Process of 2-[2-(2-Fluoroethoxy)ethoxy]ethanol

There total 2 articles about 2-[2-(2-Fluoroethoxy)ethoxy]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

triethylene glycol di-(p-toluenesulfonate) (19249-03-7) → 2-(2-(2-fluoroethoxy)ethoxy)ethanol (373-45-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Reflux; Inert atmosphere;

Reference yield:

oxirane (75-21-8,99932-75-9) + 2-fluoroethanol (371-62-0) → 2-(2-(2-fluoroethoxy)ethoxy)ethanol (373-45-5) + 2-(2-fluoroethoxy)ethanol (373-22-8)

Guidance literature:

With sodium sulfate; at 130 ℃;

Reference yield: 99.0%

2-(2-(2-fluoroethoxy)ethoxy)ethanol (373-45-5) + 3-nitro-4-chlorophenol (610-78-6) → 1-chloro-4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-2-nitrobenzene (1181376-60-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

upstream raw materials:

oxirane

2-fluoroethanol

triethylene glycol di-(p-toluenesulfonate)

Downstream raw materials:

(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-dimethylaminophenyl)-ethylene

(E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-methylaminophenyl)-ethylene

tert-butyl (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

(E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate