3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

Base Information

Chemical Name:3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide
CAS No.:1123581-47-4
Molecular Formula:C₂₁H₁₄F₃N₃O₂S
Molecular Weight:429.422
Hs Code.:

Synonyms:3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

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Chemical Property of 3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

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Technology Process of 3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

There total 1 articles about 3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1123581-45-2
3-(4-aminophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide

: 333-20-0
potassium thioacyanate

: 1123581-47-4
3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

Guidance literature:: 3-(4-aminophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide; potassium thioacyanate; With acetic acid; at 20 ℃; for 0.5h;

With bromine; at 20 ℃; Cooling with ice;

With sodium hydroxide; In water;

Reference yield: 88.0%

: 1123581-47-4
3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1123581-36-1
3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)-N-[4-(trifluoromethyl)phenyl]benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 57.0%

: 1123581-47-4
3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide

: 13831-31-7
Acetoxyacetyl chloride

: 1123581-49-6
3-{[2-(glycoloylamino)-1,3-benzothiazol-6-yl]oxy}-N-[4-(trifluoromethyl)phenyl]benzamide

Guidance literature:: 3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-N-[4-(trifluoromethyl)phenyl]benzamide; Acetoxyacetyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; Cooling with ice;