3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone

Base Information

• Chemical Name: 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone
• CAS No.: 95437-39-1
• Molecular Formula: C₂₃H₂₃NO
• Molecular Weight: 329.442
• Mol file: 95437-39-1.mol

Synonyms:3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone

Chemical Property of 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone

There total 5 articles about 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methyl-benzaldehyde (104-87-0) + p-toluidine (106-49-0,12221-03-3) + acetophenone (98-86-2) → 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone (95437-39-1)

Guidance literature:

With silica-supported organocatalyst based on trifluoroacetic acid; In neat (no solvent); at 20 ℃; for 0.25h;

DOI:10.1080/00397911.2015.1105983

Reference yield:

4-methyl-chalcone (4224-87-7) + p-toluidine (106-49-0,12221-03-3) → 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone (95437-39-1)

Guidance literature:

for 4h; Green chemistry;

DOI:10.1016/j.tetlet.2015.02.088

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 3-(4-methylphenyl)-1-phenyl-3-(4-toluidino)-1-propanone (95437-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: alkylphenylsulfonic acid functionalized silica coated magnetic Fe₃O₄ nanoparticle / ethanol / 20 °C / Green chemistry

2: 4 h / Green chemistry

With alkylphenylsulfonic acid functionalized silica coated magnetic Fe₃O₄ nanoparticle; In ethanol;

DOI:10.1016/j.tetlet.2015.02.088

upstream raw materials:

4-methyl-benzaldehyde

p-toluidine

acetophenone

4-methyl-chalcone