3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide

Base Information

• Chemical Name: 3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide
• CAS No.: 1443053-25-5
• Molecular Formula: C₃₁H₃₃N₃O₅
• Molecular Weight: 527.62

Synonyms:3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide

Chemical Property of 3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide

There total 6 articles about 3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3,4-bis(benzyloxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate (1443053-95-9) + ethanamine hydrochloride (557-66-4) → 3,4-bis(benzyloxy)-N2-ethyl-1-(4-methoxyphenyl)-N5,N5-dimethyl-1H-pyrrole-2,5-dicarboxamide (1443053-25-5)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

diethyl 3,4-bis(benzyloxy)-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate (1443053-92-6) → 3,4-bis(benzyloxy)-N2-ethyl-1-(4-methoxyphenyl)-N5,N5-dimethyl-1H-pyrrole-2,5-dicarboxamide (1443053-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / tetrahydrofuran; ethanol / 16 h / 50 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3: isopropylmagnesium chloride / tetrahydrofuran / 18 h / 20 °C

With water; isopropylmagnesium chloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate (98269-30-8) → 3,4-bis(benzyloxy)-N2-ethyl-1-(4-methoxyphenyl)-N5,N5-dimethyl-1H-pyrrole-2,5-dicarboxamide (1443053-25-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol / 1 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3: sodium hydroxide; water / tetrahydrofuran; ethanol / 16 h / 50 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5: isopropylmagnesium chloride / tetrahydrofuran / 18 h / 20 °C

With water; isopropylmagnesium chloride; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

diethyl 3,4-bis(benzyloxy)-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate

triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

diethyl 3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylate

Downstream raw materials:

N²-ethyl-3,4-dihydroxy-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1443053-25-5 3,4-bis(benzyloxy)-N²-ethyl-1-(4-methoxyphenyl)-N⁵,N⁵-dimethyl-1H-pyrrole-2,5-dicarboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send