[(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Base Information

• Chemical Name: [(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine
• CAS No.: 107496-24-2
• Molecular Formula: C₂₆H₃₈N₂OSi
• Molecular Weight: 422.686
• Mol file: 107496-24-2.mol

Synonyms:[(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Chemical Property of [(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

There total 9 articles about [(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

t-butyldimethylsiyl triflate (69739-34-0) + (+)-(S)-1-(1,2-diphenyl-ethylideneamino)-2-methoxymethyl pyrrolidine (107538-62-5) → (+)-(2S,2'R)-1-<2'-(t-Butyldimethylsilyl)-2'-phenylphenyleth-1'-ylideneamino>-2-methoxymethylpyrrolidine (107496-24-2)

Guidance literature:

With lithium diisopropyl amide; In diethyl ether; hexane; 1.) 0 deg C, 4 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.;

Reference yield:

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) → (+)-(2S,2'R)-1-<2'-(t-Butyldimethylsilyl)-2'-phenylphenyleth-1'-ylideneamino>-2-methoxymethylpyrrolidine (107496-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 4 Angstroem molecular sieves / benzene / Ambient temperature

2: 64 percent / LDA / diethyl ether; hexane / 1.) 0 deg C, 4 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

With 4 A molecular sieve; lithium diisopropyl amide; In diethyl ether; hexane; benzene;

Reference yield:

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) → [(R)-2-(tert-Butyl-dimethyl-silanyl)-1,2-diphenyl-eth-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine (107496-24-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 1) lithium diisopropylamide / 1) ether, 0 deg C, 4 h, 2) -78 deg C, 2 h; 10 h, -78 deg C to RT

With lithium diisopropyl amide;

upstream raw materials:

t-butyldimethylsiyl triflate

(+)-(S)-1-(1,2-diphenyl-ethylideneamino)-2-methoxymethyl pyrrolidine

phenyl benzyl ketone

(S)-N-Nitroso-O-methylprolinol

Downstream raw materials:

(-)-(R)-2-(t-Butyldimethylsilyl)-1,2-diphenylethanone

(S)-N-Nitroso-O-methylprolinol