3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

Base Information

Chemical Name:3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione
CAS No.:1323405-76-0
Molecular Formula:C₃₁H₃₂N₄O₄
Molecular Weight:524.619
Hs Code.:

Synonyms:3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

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Chemical Property of 3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

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Technology Process of 3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

There total 13 articles about 3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 92-54-6
4-phenyl-1-piperazine

: 1323407-86-8
3-[4-[[4-(bromomethyl)phenyl]methoxy]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione

: 1323405-76-0
3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 4-[4-(tert-butyl-dimethyl-silanyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-4-carbamoyl-butyric acid methyl ester

: 1323405-76-0
3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide; water / 15 h / 15 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 16 h / 60 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 1323407-17-5
2-bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester

: 1323405-76-0
3-(1-oxo-4-((4-((4-phenylpiperazin-1-yl)methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; water / 15 h / 15 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 16 h / 60 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928