Technology Process of N,N-bis(tert-butoxycarbonyl)-3-(1-(2,5-difluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
There total 7 articles about N,N-bis(tert-butoxycarbonyl)-3-(1-(2,5-difluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate;
In
dimethyl sulfoxide;
at 80 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
1.2: 0 - 20 °C
2.1: hydrogenchloride; iron / 3 h / 100 °C
3.1: N-Bromosuccinimide / acetonitrile / 0.67 h / 0 °C
4.1: dmap / N,N-dimethyl-formamide / 24 h / 20 °C
5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere
With
hydrogenchloride; dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; iron; sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride; iron / 3 h / 100 °C
2: N-Bromosuccinimide / acetonitrile / 0.67 h / 0 °C
3: dmap / N,N-dimethyl-formamide / 24 h / 20 °C
4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere
With
hydrogenchloride; dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; iron;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;