N-(4-ethynylphenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-ethynylphenyl)methanesulfonamide
CAS No.:111448-81-8
Molecular Formula:C₉H₉NO₂S
Molecular Weight:195.242
Hs Code.:2935909099
DSSTox Substance ID:DTXSID401287932

Synonyms:N-(4-ethynylphenyl)methanesulfonamide;111448-81-8;SCHEMBL478987;UCHWGULVMAZIMT-UHFFFAOYSA-N;DTXSID401287932;MFCD03012027;AKOS006240690;N-(4-ethynyl-phenyl)-methanesulfonamide;CS-0259998;FT-0713940;E82607;EN300-744005;1T-1150;N-(4-ethynylphenyl)methanesulfonamide, AldrichCPR

Suppliers and Price of N-(4-ethynylphenyl)methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Apolloscientific
N-(4-Ethynylphenyl)methanesulfonamide
1g
$ 1283.00

American Custom Chemicals Corporation
N-(4-ETHYNYLPHENYL)METHANESULFONAMIDE 95.00%
5MG
$ 496.12

Total 3 raw suppliers

Chemical Property of N-(4-ethynylphenyl)methanesulfonamide

Chemical Property:

Boiling Point:314.9±44.0 °C(Predicted)
Density:1.28±0.1 g/cm3(Predicted)
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:195.03539970
Heavy Atom Count:13
Complexity:298

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Ethynylphenyl)methanesulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)NC1=CC=C(C=C1)C#C

Technology Process of N-(4-ethynylphenyl)methanesulfonamide

There total 7 articles about N-(4-ethynylphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 14235-81-5
4-Ethynylaniline

: 124-63-0
methanesulfonyl chloride

: 111448-81-8
N-(4-ethynylphenyl)methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2021.113514

Reference yield: 90.0%

: N-(4-((trimethylsilyl)ethynyl)phenyl)methanesulfonamide

: 111448-81-8
N-(4-ethynylphenyl)methanesulfonamide

Guidance literature:: With potassium fluoride; In methanol; at 20 ℃; for 3h; Reagent/catalyst;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 111448-81-8
N-(4-ethynylphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 2 h / 0 °C

2: copper(l) iodide; triethylamine; trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran; triethylamine / 4 h / 40 - 65 °C / Inert atmosphere

3: potassium fluoride / methanol / 3 h / 20 °C

With pyridine; potassium fluoride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; triethylamine;