2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride

Base Information

• Chemical Name: 2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride
• CAS No.: 1073435-74-1
• Molecular Formula: C₁₅H₁₄ClF₂NO₃*ClH
• Molecular Weight: 366.192

Synonyms:2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride

Chemical Property of 2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride

Chemical Property:

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Technology Process of 2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride

There total 1 articles about 2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline (1073435-72-9) → 2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride (1073435-74-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Cooling with ice;

Reference yield:

2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester (3177-20-6) + 2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride (1073435-74-1) → methyl 2-chloro-4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-pyrimidine-5-carboxylate (1073438-02-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 120 ℃; for 2h;

Reference yield:

2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline hydrochloride (1073435-74-1) + ethyl 4-chloro-2-methoxypyrimidine-5-carboxylate (65269-18-3) → ethyl 4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-2-methoxypyrimidine-5-carboxylate (1073438-00-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 1.5h; Reflux;

upstream raw materials:

2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyaniline

Downstream raw materials:

methyl 2-chloro-4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-pyrimidine-5-carboxylate

ethyl 4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-2-methoxypyrimidine-5-carboxylate

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