65269-18-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-chloro-2-methoxypyrimidine-5-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity enable the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, ethyl 4-chloro-2-methoxypyrimidine-5-carboxylate serves as an important intermediate for the production of pesticides. Its incorporation into these compounds helps enhance their effectiveness in controlling pests and diseases in agriculture.
Used in Medicinal Chemistry Research:
Ethyl 4-chloro-2-methoxypyrimidine-5-carboxylate is utilized as a valuable compound in medicinal chemistry research. Its potential biological activity and diverse functional groups make it a promising candidate for the discovery and development of novel therapeutic agents.

InChI:InChI=1/C8H9ClN2O3/c1-3-14-7(12)5-4-10-8(13-2)11-6(5)9/h4H,3H2,1-2H3

Upstream product

• 65407-49-0 2-methoxy-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 51940-64-8 ethyl 2,4-dichloropyrimidine-5-carboxylate 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 1073438-00-2 ethyl 4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-2-methoxypyrimidine-5-carboxylate 

Relevant academic research and scientific papers

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

5-PHENOXY-3H-PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein R1, R2, RE, L, M and Z are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Process for the preparation of 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidines

Process for the preparation of a 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine of the formula: STR1 IN WHICH R1 is a lower alkyl radical with 1 to 4 carbon atoms, which comprises the following stages: A) condensation of a salt of O-methylisourea and an inorganic or organic acid, with an alkyl alkoxymethylenemalonate STR2 in an aqueous medium and in the presence of an excess of an alkali metal hydroxide, to form the corresponding salt of the 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and neutralization of the said salt by the addition of an inorganic or organic acid, in order to liberate this 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and STR3 B) bringing the latter compound, suspended in dimethylformamide, into contact with thionyl chloride, at room temperature, in order to form the corresponding 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine: STR4