(R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine

Base Information

• Chemical Name: (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine
• CAS No.: 1026790-40-8
• Molecular Formula: C₂₈H₂₈F₂N₆O₃
• Molecular Weight: 534.566

Synonyms:(R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine

Chemical Property of (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine

Chemical Property:

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Technology Process of (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine

There total 15 articles about (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N4-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine (911826-25-0) → (R)-N2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N4-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine (1026790-40-8)

Guidance literature:

With hydrogen; Raney nickel; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

(R)-N-(8-fluorochroman-4-yl)-2-methoxyacetamide (911826-29-4) → (R)-N2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N4-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine (1026790-40-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; ethanol; water / 4 h / Heating / reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

3: potassium carbonate / acetonitrile / 3 h / 65 °C

4: hydrogen / nickel / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; ethanol; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; nickel; In tetrahydrofuran; acetonitrile;

Reference yield:

8-fluorochroman-4-amine (791043-28-2) → (R)-N2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N4-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine (1026790-40-8)

Guidance literature:

Multi-step reaction with 5 steps

1: novozyme 435 / tert-butyl methyl ether / 2 h / Heating / reflux; Enzymatic reaction; Resolution of racemate

2: hydrogenchloride; ethanol; water / 4 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

4: potassium carbonate / acetonitrile / 3 h / 65 °C

5: hydrogen / nickel / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; ethanol; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; novozyme 435; nickel; In tetrahydrofuran; tert-butyl methyl ether; acetonitrile;

upstream raw materials:

(R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine

(R)-8-fluorochroman-4-amine

8-fluorochroman-4-amine

(R)-N-(8-fluorochroman-4-yl)-2-methoxyacetamide

Downstream raw materials:

(R)-2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

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