diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate

Base Information

• Chemical Name: diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate
• CAS No.: 94961-25-8
• Molecular Formula: C₂₁H₂₅NO₆S
• Molecular Weight: 419.499
• Mol file: 94961-25-8.mol

Synonyms:diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate

Chemical Property of diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate

There total 3 articles about diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

phenyl N-tosyl imine (51608-60-7) + diethyl malonate (105-53-3) → diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate (94961-25-8)

Guidance literature:

With 1-(3,5-bis(CF₃)C₆H₃)-3-((1R,2R)-2-Me₂N-cyclohexyl)thiourea; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-2007-983795

Reference yield: 14.0%

N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) + diethyl malonate (105-53-3) → diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate (94961-25-8) + 2-phenyl-1,1,3,3-tetraethoxycarbonylpropane (6768-26-9) + diethyl benzalmalonate (5292-53-5)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 50 ℃;

DOI:10.1021/jo070726e

Reference yield:

→ diethyl 2-((4-methylphenylsulfonamido)(phenyl)methyl)malonate (94961-25-8)

Guidance literature:

Na-Malonester, 1) /BRN= 115660/, 2) Hydrolyse;

upstream raw materials:

N-(benzylidene)-p-methylbenzenesulfonamide

diethyl malonate

phenyl N-tosyl imine

Downstream raw materials:

diethyl benzalmalonate

2-phenyl-1,1,3,3-tetraethoxycarbonylpropane

diethyl 3-phenyl-1-tosylaziridine-2,2-dicarboxylate

3-phenylglutaric acid