2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

Base Information

Chemical Name:2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid
CAS No.:357933-49-4
Molecular Formula:C₂₄H₂₈N₇O₁₀P
Molecular Weight:605.501
Hs Code.:

Synonyms:2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

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Chemical Property of 2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

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Technology Process of 2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

There total 5 articles about 2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 357933-46-1
2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester

: 357933-49-4
2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Na / ethanol / 80 °C

2.1: H₂ / Pd/C / ethanol

2.2: 88 percent / conc. HCl / 20 h / Heating

3.1: tetramethylguanidine / dimethylsulfoxide / 18 h / 20 °C

With 1,1,3,3-tetramethylguanidine; hydrogen; sodium; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jo010283t

Reference yield:

: 357933-48-3
2-(ethoxycarbonyl)-2-(acetamido)-4-[(2,4-dibenzoxycarbonylbutyl)(ethoxy)phosphinyl]butanoic acid ethyl ester

: 357933-49-4
2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / ethanol

1.2: 88 percent / conc. HCl / 20 h / Heating

2.1: tetramethylguanidine / dimethylsulfoxide / 18 h / 20 °C

With 1,1,3,3-tetramethylguanidine; hydrogen; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jo010283t

Reference yield:

: 223378-68-5
N¹⁰-(trifluoroacetyl)pyrofolic acid

: 357933-49-4
2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / hydrazine monohydrate / dimethylsulfoxide / 18 h / 20 °C

2: 83 percent / t-BuONO; KSCN; TFA / 6.5 h / -10 °C

3: tetramethylguanidine / dimethylsulfoxide / 18 h / 20 °C

With tert.-butylnitrite; 1,1,3,3-tetramethylguanidine; potassium thioacyanate; hydrazine hydrate; trifluoroacetic acid; In dimethyl sulfoxide;
DOI:10.1021/jo010283t