2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester

Base Information

• Chemical Name: 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester
• CAS No.: 357933-46-1
• Molecular Formula: C₂₄H₂₉O₆P
• Molecular Weight: 444.464
• Mol file: 357933-46-1.mol

Synonyms:

Chemical Property of 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester

There total 3 articles about 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dibenzyl 2-methylenepentanedioate (173039-05-9) → 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester (357933-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂POONH₄; hexamethyldisilazane / CH₂Cl₂ / 24 h / 20 °C

2.1: various solvent(s)

3.1: 20 h / 120 °C

3.2: 1.71 g / 1.5 h / Heating

With ammonium hypophosphorous acid; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;

DOI:10.1021/jo010283t

Reference yield:

2,4-di(benzyloxycarbonyl)butylphosphinic acid (200698-34-6) → 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester (357933-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: various solvent(s)

2.1: 20 h / 120 °C

2.2: 1.71 g / 1.5 h / Heating

In various solvent(s);

DOI:10.1021/jo010283t

Reference yield:

ethylene dibromide (106-93-4) + orthoformic acid triethyl ester (122-51-0) + (CH3)3SiOP(OSi(CH3)3)CH2CH(CO2CH2C6H5)CH2CH2CO2CH2C6H5 → 2-[(ethoxy(vinyl)phosphinyl)methyl]pentane-1,5-dioic acid dibenzyl ester (357933-46-1)

Guidance literature:

ethylene dibromide; (CH₃)3SiOP(OSi(CH₃)3)CH₂CH(CO₂CH₂C₆H₅)CH₂CH₂CO₂CH₂C₆H₅; at 120 ℃; for 20h;

orthoformic acid triethyl ester; for 1.5h; Further stages.; Heating;

DOI:10.1021/jo010283t

upstream raw materials:

ethylene dibromide

orthoformic acid triethyl ester

dibenzyl 2-methylenepentanedioate

2,4-di(benzyloxycarbonyl)butylphosphinic acid

Downstream raw materials:

2-[[[3-carboxy-3-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

2-[[[3-carboxy-3-[[4-[[(2-amino-3,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]amino]propyl]hydroxyphosphinyl]methyl]pentane-1,5-dioic acid

Refernces