pteroyl hydrazide

Base Information

• Chemical Name: pteroyl hydrazide
• CAS No.: 197151-68-1
• Molecular Formula: C₁₄H₁₄N₈O₂
• Molecular Weight: 326.318
• Mol file: 197151-68-1.mol

Synonyms:pteroyl hydrazide

Chemical Property of pteroyl hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of pteroyl hydrazide

There total 15 articles about pteroyl hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N10-(trifluoroacetyl)pyrofolic acid (223378-68-5) → pteroyl hydrazide (197151-68-1)

Guidance literature:

With hydrazine hydrate; In dimethyl sulfoxide; at 20 ℃; for 18h;

DOI:10.1021/jo010283t

Reference yield: 91.0%

N10-(trifluoroacetyl)pyrofolic acid (223378-68-5) → pteroyl hydrazide (197151-68-1) + folic acid-hydrazide + Pyroglutamic acid (149-87-1)

Guidance literature:

With hydrazine; In dimethyl sulfoxide; at 25 ℃; for 8h;

DOI:10.1021/ja971568j

Reference yield: 90.0%

pyrofolic acid (223378-69-6) → pteroyl hydrazide (197151-68-1) + folic acid-hydrazide + Pyroglutamic acid (149-87-1)

Guidance literature:

With hydrazine; In dimethylsulfoxide-d6; at 25 ℃; for 9h;

DOI:10.1021/ja971568j

upstream raw materials:

pyrofolic acid

N¹⁰-(trifluoroacetyl)pyrofolic acid

folic acid

pteroyl azide

Downstream raw materials:

pteroyl azide

N¹⁰-nitrosopteroyl azide

pteroyl-lys

pteroyl-lys-HYNIC

Refernces

• 1、 Bertuzzi, Diego L.,Braga, Carolyne B.,Ornelas, Catia,Perli, Gabriel. "Synthesis, characterization, and anticancer activity of folate γ-ferrocenyl conjugates". . p. 4694 - 4703. Retrieved 2020/04/03.
• 2、 Smith, Bryan D.,Higgin, Joshua J.,Raines, Ronald T.. "Site-specific folate conjugation to a cytotoxic protein". experimental part. p. 5029 - 5032. Retrieved 2011/10/09.