(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Base Information

Chemical Name:(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
CAS No.:1253197-33-9
Molecular Formula:C₃₂H₃₈FNO₄
Molecular Weight:519.656
Hs Code.:

Synonyms:(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Chemical Property of (+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Technology Process of (+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

There total 10 articles about (+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1253197-26-0
(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 36714-65-5
(chloro-3 propyl)-2 (fluoro-4 phenyl)-2 dimethyl-5,5 dioxanne-1,3

: 1253197-33-9
(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; for 62h; Reflux;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 81593-57-9
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

: 1253197-33-9
(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

1.2: 1 h / Cooling with ice

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

4.1: methanol; magnesium / 5 h / Reflux

5.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 62 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In dichloromethane; acetone; acetonitrile;

Reference yield:

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 1253197-33-9
(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 8 h / Dean-Stark; Reflux

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 62 h / Reflux

With tetra-(n-butyl)ammonium iodide; potassium carbonate; toluene-4-sulfonic acid; In toluene; acetonitrile;