2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1061728-10-6
Molecular Formula:C₂₄H₃₆N₂O₈
Molecular Weight:480.558
Hs Code.:

Synonyms:2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 7 articles about 2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132307-20-1
2-((E)-2-Ethoxycarbonyl-vinyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1061728-10-6
2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.42.551

Reference yield:

: 89941-07-1
ethyl 2-piperazinecarboxylate

: 1061728-10-6
2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: LiCl, NaBH₄ / ethanol; tetrahydrofuran / 12 h / Ambient temperature

4: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 5 min, 2.) CH₂Cl₂, from -78 deg C to RT

5: toluene / 3 h / 50 °C

6: H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr / Ambient temperature

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1248/cpb.42.551

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1061728-10-6
2-(2-Ethoxycarbonyl-ethyl)-4-(3,4,5-trimethoxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: LiCl, NaBH₄ / ethanol; tetrahydrofuran / 12 h / Ambient temperature

4: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 5 min, 2.) CH₂Cl₂, from -78 deg C to RT

5: toluene / 3 h / 50 °C

6: H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr / Ambient temperature

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1248/cpb.42.551