Ethyl Piperazine-2-carboxylate

Base Information

• Chemical Name: Ethyl Piperazine-2-carboxylate
• CAS No.: 89941-07-1
• Molecular Formula: C7H14N2O2
• Molecular Weight: 158.2
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID30442797
• Nikkaji Number: J1.921.804J
• Mol file: 89941-07-1.mol

Synonyms:Ethyl Piperazine-2-carboxylate;89941-07-1;Ethyl 2-piperazinecarboxylate;Ethyl-2-piperazinecarboxylate;Ethyl,Piperazine-2-carboxylate;PIPERAZINE-2-CARBOXYLIC ACID ETHYL ESTER;2-ethoxycarbonylpiperazine;2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER;SCHEMBL1417951;DTXSID30442797;XWZHSYWFWDKJHI-UHFFFAOYSA-N;BCP27512;MFCD03265251;AKOS006279446;AB13833;FS-6510;2-piperazine-carboxylic acid ethyl ester;Piperazine 2-carboxylic acid ethyl ester;AC-10293;Piperazine 2- carboxylic acid ethyl ester;FT-0651520;EN300-91494;J-521277

Chemical Property of Ethyl Piperazine-2-carboxylate

Chemical Property:

• Vapor Pressure: 0.036mmHg at 25°C
• Melting Point: 62-64 °C(Solv: ethyl ether (60-29-7))
• Refractive Index: 1.446
• Boiling Point: 241.364 °C at 760 mmHg
• PKA: 8.12±0.40(Predicted)
• Flash Point: 99.774 °C
• PSA: 50.36000
• Density: 1.036g/cm³
• LogP: -0.23150
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 158.105527694
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

2-Piperazinecarboxylic acid ethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1CNCCN1

Technology Process of Ethyl Piperazine-2-carboxylate

There total 6 articles about Ethyl Piperazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ ethyl 2-piperazinecarboxylate (89941-07-1)

Guidance literature:

Reference yield: 98.0%

ethyl 1,4-dibenzylpiperazin-2-carboxylate (72351-59-8) → ethyl 2-piperazinecarboxylate (89941-07-1)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol;

Reference yield:

aqueous potassium carbonate + sulfuric acid (7664-93-9) + piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) → ethyl 2-piperazinecarboxylate (89941-07-1)

Guidance literature:

In ethanol; toluene;

upstream raw materials:

ethanol

ethyl 1,4-dibenzylpiperazin-2-carboxylate

sulfuric acid

piperazine-2-carboxylic acid dihydrochloride

Downstream raw materials:

ethyl 1-(4,4-diphenyl-3-butene-1-yl)piperazine-3-carboxylate

5-Piperazin-2-yl-[1,2,4]oxadiazol-3-ylamine

ethyl 4-(3,4,5-trimethoxybenzoyl)piperazine-2-carboxylate

1-tritylpiperazin-3yl-carboxylic acid ethyl ester

Refernces

• 1、 Kracht, Daniel,Saito, Susumu,Wuensch, Bernhard. "Synthesis of 1,4-diazabicyclo[3.3.1]nonan-6-ones". experimental part. p. 1684 - 1689. Retrieved 2010/07/02.
• 2、 -. "Calcium channel inhibitors comprising benzhydril spaced from piperazine". . . Retrieved 2008/06/13.