89941-07-1

Basic information

• Product Name: ETHYL-2-PIPERAZINECARBOXYLATE
• Synonyms: 1-Ethylpiperazine-2-carboxylate;ETHYL-2-PIPERAZINECARBOXYLATE HCL;ETHYL-2-PIPERAZINECARBOXYLATE;2-Piperazinecarboxylicacid,ethylester(6CI,7CI,9CI);ETHYL PIPERAZINE-2-CARBOXYLATE;2-Piperazinecarboxylic acid, ethyl ester
• CAS NO: 89941-07-1
• Molecular Formula: C₇H₁₄N₂O₂
• Molecular Weight: 158.2
• Product Categories: Heterocycle-other series;PIPERIDINE;pharmacetical
• Mol File: 89941-07-1.mol

Chemical Properties

• Melting Point: 62-64 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 241.364 °C at 760 mmHg
• Flash Point: 99.774 °C
• Appearance: /
• Density: 1.036g/cm³
• Vapor Pressure: 0.036mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.12±0.40(Predicted)
• CAS DataBase Reference: ETHYL-2-PIPERAZINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL-2-PIPERAZINECARBOXYLATE(89941-07-1)
• EPA Substance Registry System: ETHYL-2-PIPERAZINECARBOXYLATE(89941-07-1)

Safety Data

• Hazardous Substances Data: 89941-07-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl-2-piperazinecarboxylate is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of antihistamines, antipsychotics, and antimalarial drugs. Its chemical properties make it a valuable component in creating effective medications for a wide array of medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, ethyl-2-piperazinecarboxylate serves as an intermediate in the production of various agrochemicals, playing a crucial role in the development of compounds that protect crops and enhance agricultural productivity.
Used as a Corrosion Inhibitor:
Ethyl-2-piperazinecarboxylate is utilized as a corrosion inhibitor, providing protection to materials from the damaging effects of corrosive agents, thereby extending the service life of equipment and structures in various industries.
Used in Surfactant and Lubricant Synthesis:
ETHYL-2-PIPERAZINECARBOXYLATE is also used as a component in the synthesis of surfactants and lubricants, where it contributes to the formulation of products that reduce friction and improve the performance of various industrial applications.
Used in Medical Research:
Ethyl-2-piperazinecarboxylate has been studied for its potential use in the treatment of various medical conditions, including cancer and neurodegenerative diseases, indicating its broad applicability in the field of medical research and therapeutic development.

InChI:InChI=1/C7H14N2O2/c1-2-11-7(10)6-5-8-3-4-9-6/h6,8-9H,2-5H2,1H3

Upstream product

• 64-17-5 ethanol 
• 72351-59-8 ethyl 1,4-dibenzylpiperazin-2-carboxylate 
• 3674-13-3 2,3-dibromopropionic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 3022-15-9 piperazine-2-carboxylic acid dihydrochloride 

Downstream Products

• 155672-58-5 ethyl 1-(4,4-diphenyl-3-butene-1-yl)piperazine-3-carboxylate 
• 129594-95-2 5-Piperazin-2-yl-[1,2,4]oxadiazol-3-ylamine 
• 129798-93-2 ethyl 4-(3,4,5-trimethoxybenzoyl)piperazine-2-carboxylate 
• 162510-56-7 1-tritylpiperazin-3yl-carboxylic acid ethyl ester 
• 183742-29-2 piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 85817-46-5 4-benzhydryl-piperazine-2-carboxylic acid ethyl ester 
• 156727-93-4 ethyl 4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate 
• 129799-63-9 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine-2-methanol 
• 156727-95-6 ethyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate 
• 129799-44-6 methyl 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate 

Relevant articles and documents

COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USES AS IDH1 MUTANTS INHIBITORS FOR TREATING CANCERS

Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses as IDH1 mutants inhibitors for treating cancers are also provided

Synthesis of 1,4-diazabicyclo[3.3.1]nonan-6-ones

1,4-Diazabicyclo[3.3.1]nonanes (aza-morphans) represent conformationally constrained piperazine derivatives. Herein, we report a six-step synthesis of the benzyl and allyl substituted bicyclic ketones 3a and 3b, which represent interesting building blocks

BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF

The present invention provides a compound represented by the formula: wherein R1 is an acyl group, R2 is a hydrocarbon group which may be substituted or the like, R3 is a hydrocarbon group which may be substituted or the like, R4 is a hydrocarbon group which may be substituted or the like, n is from 0 to 4, and X is an oxygen atom, a sulfur atom or the like, or a salt thereof. The invention also provides a compound which has a TGR23 antagonist activity and thus is useful for prevention and treatment of cancer.

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

Calcium channel inhibitors comprising benzhydril spaced from piperazine

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

Calcium channel blockers comprising two benzhydril moieties

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Carboxylic acids and the esters thereof, pharmaceutical compositions thereto and processes for the preparation thereof

The present invention relates to carboxylic acids and esters of general formula wherein Ar, R, R1, X1, X3, X4, Y and Y1 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof, as well as the use thereof for the production and purification of antibodies and as labelled compounds in RIA and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.