tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Base Information

Chemical Name:tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate
CAS No.:1056555-23-7
Molecular Formula:C₄₄H₅₉Cl₂N₃O₇
Molecular Weight:812.874
Hs Code.:

tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Synonyms:tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

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Chemical Property of tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

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Technology Process of tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

There total 15 articles about tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5050-41-9
N-(2-chloroethyl)-pyrrolidine

: 1056555-21-5
tert-butyl (3-[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

: 1056555-23-7
tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

Reference yield:

: 1026786-84-4
3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde

: 1056555-23-7
tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: magnesium sulfate / dichloromethane / 12 h / 20 °C

2.2: 3 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1026786-87-7
3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

: 1056555-23-7
tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-(2-pyrrolidin-1-ylethoxy)benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium sulfate / dichloromethane / 12 h / 20 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;