3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

Base Information

Chemical Name:3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde
CAS No.:1026786-87-7
Molecular Formula:C₁₇H₂₆O₃Si
Molecular Weight:306.477
Hs Code.:

Synonyms:3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

Chemical Property:

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Technology Process of 3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

There total 3 articles about 3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026786-84-4
3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1026786-87-7
3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 199177-26-9
3-bromo-5-hydroxybenzaldehyde

: 1026786-87-7
3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; sodium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 16 h / 80 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; palladium diacetate; sodium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.02.067

Reference yield:

: 626-41-5
3,5-dibromophenol

: 1026786-87-7
3-((tert-butyl(dimethyl)silyl)oxy)-5-[(1E)-3-methoxy-prop-1-en-1-yl]-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; butyl magnesium bromide / toluene / 0.5 h / -10 °C

1.2: 1 h / -40 - 20 °C

2.1: palladium diacetate; sodium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 16 h / 80 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; n-butyllithium; butyl magnesium bromide; palladium diacetate; sodium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.02.067