(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

Base Information

Chemical Name:(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate
CAS No.:1355052-64-0
Molecular Formula:C₂₁H₁₈FNO₅
Molecular Weight:383.376
Hs Code.:

Synonyms:(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

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Chemical Property of (S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

Chemical Property:

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Technology Process of (S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

There total 8 articles about (S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355052-63-9
methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

: 1355052-64-0
(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

Guidance literature:: With (DHQ)2PHAL; water; isopropyl alcohol; for 3h;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1355052-64-0
(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

3.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

3.2: 0.5 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Inert atmosphere; Reflux

6.1: tetrabutyl ammonium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2 h / 80 °C / Inert atmosphere

7.1: isopropyl alcohol; water; (DHQ)2PHAL / 3 h

With (DHQ)2PHAL; sulfuric acid; tetrabutyl ammonium fluoride; water; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; isopropyl alcohol; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1355052-64-0
(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

3.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

3.2: 0.5 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Inert atmosphere; Reflux

6.1: tetrabutyl ammonium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2 h / 80 °C / Inert atmosphere

7.1: isopropyl alcohol; water; (DHQ)2PHAL / 3 h

With (DHQ)2PHAL; sulfuric acid; tetrabutyl ammonium fluoride; water; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; isopropyl alcohol; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;