methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

Base Information

Chemical Name:methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate
CAS No.:1355052-63-9
Molecular Formula:C₂₁H₁₆FNO₃
Molecular Weight:349.361
Hs Code.:

Synonyms:methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

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Chemical Property of methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

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Technology Process of methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

There total 7 articles about methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1355052-62-8
methyl 4-chloro-6-(4-(4-fluorophenoxy)phenyl)picolinate

: 75927-49-0
pinacol vinylboronate

: 1355052-63-9
methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

Guidance literature:: With tetrabutyl ammonium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1355052-63-9
methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

3.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

3.2: 0.5 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Inert atmosphere; Reflux

6.1: tetrabutyl ammonium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2 h / 80 °C / Inert atmosphere

With sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2561-25-3
4-(4-fluorophenoxy)-1-nitrobenzene

: 1355052-63-9
methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

2.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

2.2: 0.5 h / 0 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Inert atmosphere; Reflux

5.1: tetrabutyl ammonium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2 h / 80 °C / Inert atmosphere

With sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; sodium carbonate; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;