{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

Base Information

Chemical Name:{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine
CAS No.:1281922-81-3
Molecular Formula:C₄₁H₅₀N₄O₂Si
Molecular Weight:658.959
Hs Code.:

Synonyms:{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

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Chemical Property of {7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

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Technology Process of {7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

There total 8 articles about {7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1281922-90-4
C₄₈H₅₄N₄O₄SSi

: 1281922-81-3
{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 1h;

Reference yield:

: 303963-92-0
(3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

: 1281922-81-3
{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / 0 - 20 °C

3.1: dichloromethane; toluene / 48 h / 0 - 20 °C

4.1: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

5.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 0.17 h / 20 °C

6.1: sodium hydride; 18-crown-6 ether / tetrahydrofuran / 80 °C

6.2: 2 h / 0 - 80 °C / pH 1 - 2

7.1: dmap / dichloromethane / 20 °C

8.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 1 h / 110 °C

With dmap; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; thionyl chloride; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); cerium(III) chloride heptahydrate; hydrogen; tri-n-butyl-tin hydride; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1281922-76-6
6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-ol

: 1281922-81-3
{7-[3-tert-butoxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-indan-1-yl-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane; toluene / 48 h / 0 - 20 °C

2.1: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

3.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 0.17 h / 20 °C

4.1: sodium hydride; 18-crown-6 ether / tetrahydrofuran / 80 °C

4.2: 2 h / 0 - 80 °C / pH 1 - 2

5.1: dmap / dichloromethane / 20 °C

6.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 1 h / 110 °C

With dmap; ruthenium trichloride; sodium periodate; thionyl chloride; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;