2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

Base Information

Chemical Name:2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol
CAS No.:1281922-80-2
Molecular Formula:C₄₁H₅₀N₄O₃Si
Molecular Weight:674.958
Hs Code.:

Synonyms:2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

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Chemical Property of 2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

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Technology Process of 2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

There total 5 articles about 2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 303963-92-0
(3aR,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

: 1281922-80-2
2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.5 h / 0 - 20 °C

3.1: dichloromethane; toluene / 48 h / 0 - 20 °C

4.1: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

5.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 0.17 h / 20 °C

6.1: sodium hydride; 18-crown-6 ether / tetrahydrofuran / 80 °C

6.2: 2 h / 0 - 80 °C / pH 1 - 2

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; thionyl chloride; 18-crown-6 ether; cerium(III) chloride heptahydrate; hydrogen; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1281922-76-6
6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydrocyclopenta[1,3]dioxol-4-ol

: 1281922-80-2
2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; toluene / 48 h / 0 - 20 °C

2.1: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

3.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 0.17 h / 20 °C

4.1: sodium hydride; 18-crown-6 ether / tetrahydrofuran / 80 °C

4.2: 2 h / 0 - 80 °C / pH 1 - 2

With ruthenium trichloride; sodium periodate; thionyl chloride; 18-crown-6 ether; sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1281922-73-3
3-tert-butoxy-4-(tert-butyldiphenylsilanyloxymethyl)-cyclopentane-1,2-diol

: 1281922-80-2
2-tert-butoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-[4-(indan-1-ylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; triethylamine / dichloromethane / 0.17 h / 0 °C

2.1: sodium periodate; ruthenium trichloride / tetrachloromethane; acetonitrile; water / 0.17 h / 20 °C

3.1: sodium hydride; 18-crown-6 ether / tetrahydrofuran / 80 °C

3.2: 2 h / 0 - 80 °C / pH 1 - 2

With ruthenium trichloride; sodium periodate; thionyl chloride; 18-crown-6 ether; sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;