2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Chemical Name:2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid
CAS No.:1610369-73-7
Molecular Formula:C₂₀H₂₀N₆O₃
Molecular Weight:392.417
Hs Code.:

Synonyms:2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Chemical Property of 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Technology Process of 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

There total 6 articles about 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1610369-75-9
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610369-73-7
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile; With hydrogenchloride; methanol; In dichloromethane; acetic acid methyl ester; at 20 ℃;

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1610369-69-1
ethyl 5-(cyanomethyl)-1-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-73-7
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

2.1: potassium cyanide / methanol / 45 °C / Sealed tube

3.1: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride; methanol / dichloromethane; acetic acid methyl ester / 20 °C

4.2: 2 h / 20 °C

With hydrogenchloride; methanol; potassium cyanide; sodium azide; trifluoromethylsulfonic anhydride; oxygen; copper diacetate; triethylamine; In methanol; dichloromethane; acetic acid methyl ester; acetonitrile;

Reference yield:

: 1610369-68-0
ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-73-7
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron dimethyl-trifluoro sulphide / dichloromethane / 6 h / 0 - 20 °C

2.1: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

3.1: potassium cyanide / methanol / 45 °C / Sealed tube

4.1: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 20 °C / Inert atmosphere

5.1: hydrogenchloride; methanol / dichloromethane; acetic acid methyl ester / 20 °C

5.2: 2 h / 20 °C

With hydrogenchloride; methanol; potassium cyanide; sodium azide; boron dimethyl-trifluoro sulphide; trifluoromethylsulfonic anhydride; oxygen; copper diacetate; triethylamine; In methanol; dichloromethane; acetic acid methyl ester; acetonitrile;