2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Name:2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile
CAS No.:1610369-75-9
Molecular Formula:C₂₀H₁₉N₇O
Molecular Weight:373.417
Hs Code.:

Synonyms:2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Property of 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Technology Process of 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

There total 5 articles about 2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1610369-74-8
5-(cyanomethyl)-N-methyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-75-9
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: With sodium azide; trifluoromethylsulfonic anhydride; In acetonitrile; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 27143-07-3
ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

: 1610369-75-9
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: silver(I) acetate / toluene / 20 °C / Inert atmosphere

2: boron dimethyl-trifluoro sulphide / dichloromethane / 6 h / 0 - 20 °C

3: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

4: potassium cyanide / methanol / 45 °C / Sealed tube

5: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 20 °C / Inert atmosphere

With potassium cyanide; sodium azide; boron dimethyl-trifluoro sulphide; trifluoromethylsulfonic anhydride; oxygen; silver(I) acetate; copper diacetate; triethylamine; In methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1610369-68-0
ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-75-9
2-(3-(1-methyl-1H-tetrazol-5-yl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: boron dimethyl-trifluoro sulphide / dichloromethane / 6 h / 0 - 20 °C

2: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

3: potassium cyanide / methanol / 45 °C / Sealed tube

4: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 20 °C / Inert atmosphere

With potassium cyanide; sodium azide; boron dimethyl-trifluoro sulphide; trifluoromethylsulfonic anhydride; oxygen; copper diacetate; triethylamine; In methanol; dichloromethane; acetonitrile;