ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate
CAS No.:1610369-68-0
Molecular Formula:C₁₅H₁₇N₃O₃
Molecular Weight:287.318
Hs Code.:

Synonyms:ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

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Chemical Property of ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

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Technology Process of ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

There total 1 articles about ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 109-75-1
but-3-enenitrile

: 27143-07-3
ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

: 1610369-68-0
ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

Guidance literature:: With silver(I) acetate; In toluene; at 20 ℃; Inert atmosphere;

Reference yield: 44.0%

: 1610369-68-0
ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-69-1
ethyl 5-(cyanomethyl)-1-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

Guidance literature:: With boron dimethyl-trifluoro sulphide; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield:

: 1610369-68-0
ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-67-9
2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron dimethyl-trifluoro sulphide / dichloromethane / 6 h / 0 - 20 °C

2.1: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

3.1: potassium cyanide / methanesulfonic acid / 45 °C / Sealed tube

4.1: hydrogenchloride / acetic acid methyl ester / 168 h / 20 - 40 °C / Inert atmosphere

4.2: pH Ca_. 2

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; potassium cyanide; boron dimethyl-trifluoro sulphide; water; oxygen; copper diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanesulfonic acid; dichloromethane; acetic acid methyl ester;