4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

Base Information

Chemical Name:4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene
CAS No.:207743-11-1
Molecular Formula:C₂₂H₂₁Cl₂N₃O₆
Molecular Weight:494.331
Hs Code.:

Synonyms:4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

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Chemical Property of 4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

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Technology Process of 4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

There total 4 articles about 4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.1%

: 207743-10-0
3',3''-dichloro-4-methanesulfonyloxy-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

: 207743-11-1
4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 35 - 50 ℃; for 3h;
DOI:10.1021/jm9800595

Reference yield:

: 154023-65-1
3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone

: 207743-11-1
4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaHMDS / 1.) THF, 30 min, 2.) THF, RT, 24 h

2: 71.4 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 5.5 h / 0 °C

3: 88.5 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

4: 76.1 percent / NaN₃ / dimethylformamide / 3 h / 35 - 50 °C

With sodium azide; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800595

Reference yield:

: 159500-11-5
3',3''-dichloro-4-hydroxy-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

: 207743-11-1
4-azido-3',3''-dichloro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)-1,1-diphenyl-1-butene

Guidance literature:: Multi-step reaction with 2 steps

1: 88.5 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

2: 76.1 percent / NaN₃ / dimethylformamide / 3 h / 35 - 50 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800595