Multi-step reaction with 10 steps
1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 16.5 h / 20 °C / Cooling with ice
2.1: potassium carbonate; potassium iodide / acetonitrile / 2 h
2.2: 16 h / 20 °C
2.3: 4 h / 90 - 110 °C / Dean-Stark
3.1: potassium carbonate; benzyltri(n-butyl)ammonium chloride / dichloromethane; water / 20.5 h / 50 °C / Reflux
4.1: triethylamine; tris-(o-tolyl)phosphine; palladium diacetate / acetonitrile / 2 h / 90 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C
7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 20 °C
9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h
10.2: 0.33 h / 5 °C
10.3: 20 - 40 °C
With
hydrogenchloride; palladium diacetate; benzyltri(n-butyl)ammonium chloride; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tris-(o-tolyl)phosphine; potassium iodide;
In
1,4-dioxane; dichloromethane; water; acetonitrile;