4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

Base Information

Chemical Name:4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine
CAS No.:1287685-74-8
Molecular Formula:C₂₄H₂₇F₅N₂O₃S
Molecular Weight:518.548
Hs Code.:

Synonyms:4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

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Chemical Property of 4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

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Technology Process of 4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

There total 7 articles about 4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044769-56-3
1-(4-(trifluoromethyl)benzyl)pyrrolidin-3-ol

: 1287686-08-1
2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenol

: 1287685-74-8
4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 104197-14-0
5-bromo-1,3-difluoro-2-methoxy-benzene

: 1287685-74-8
4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With di-isopropyl azodicarboxylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5: Mitsunobu reaction;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1287685-74-8
4-(3,5-difluoro-4-(1-(4-(trihuoromethyl)benzyl)pyrrolidin-3-yloxy)phenyl)-1-(methylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With di-isopropyl azodicarboxylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5: Mitsunobu reaction;