1-cyclohexylpentane-1,5-diol

Base Information

• Chemical Name: 1-cyclohexylpentane-1,5-diol
• CAS No.: 57740-05-3
• Molecular Formula: C₁₁H₂₂O₂
• Molecular Weight: 186.294
• Mol file: 57740-05-3.mol

Synonyms:1-cyclohexylpentane-1,5-diol

Chemical Property of 1-cyclohexylpentane-1,5-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclohexylpentane-1,5-diol

There total 4 articles about 1-cyclohexylpentane-1,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

methyl 5-cyclohexyl-5-oxopentanoate (144979-12-4) → 1-cyclohexylpentane-1,5-diol (57740-05-3)

Guidance literature:

methyl 5-cyclohexyl-5-oxopentanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.tet.2010.10.068

Reference yield: 87.0%

7-Cyclohexyl-2,2-dimethyl-[1,2]oxasilepane (130276-87-8) → 1-cyclohexylpentane-1,5-diol (57740-05-3)

Guidance literature:

With dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; Heating;

DOI:10.1021/ja00178a057

Reference yield:

(S)-1-cyclohexylbut-3-en-1-ol (69036-26-6,85029-11-4,94340-22-4,106756-93-8) → 1-cyclohexylpentane-1,5-diol (57740-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 92 percent / (n-Bu)3SnCl, NaB(CN)H₃, AIBN / 2-methyl-propan-2-ol / Heating

3: 87 percent / 30percent H₂O₂, KHCO₃, / tetrahydrofuran; methanol / Heating

With 2,2'-azobis(isobutyronitrile); tributyltin chloride; dihydrogen peroxide; sodium cyanoborohydride; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;

DOI:10.1021/ja00178a057

upstream raw materials:

7-Cyclohexyl-2,2-dimethyl-[1,2]oxasilepane

(S)-1-cyclohexylbut-3-en-1-ol

Bromomethyl-((S)-1-cyclohexyl-but-3-enyloxy)-dimethyl-silane

methyl 5-cyclohexyl-5-oxopentanoate

Downstream raw materials:

2-cyclohexyltetrahydropyran