Technology Process of 3-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)propanimidamide
There total 4 articles about 3-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)propanimidamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation
2.1: sodium hydroxide / dichloromethane; water / 4 h / 0 - 20 °C
3.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 25 °C
4.1: methanol; acetyl chloride / toluene / 2.08 h / 0 - 20 °C
4.2: 0 - 20 °C
With
methanol; hydrogen; potassium carbonate; acetyl chloride; sodium hydroxide;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
2.1: Wittig Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation
2.1: sodium hydroxide / dichloromethane; water / 4 h / 0 - 20 °C
3.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 25 °C
4.1: methanol; acetyl chloride / toluene / 2.08 h / 0 - 20 °C
4.2: 0 - 20 °C
With
methanol; hydrogen; potassium carbonate; acetyl chloride; sodium hydroxide;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
2.1: Wittig Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / dichloromethane; water / 4 h / 0 - 20 °C
2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 25 °C
3.1: methanol; acetyl chloride / toluene / 2.08 h / 0 - 20 °C
3.2: 0 - 20 °C
With
methanol; hydrogen; acetyl chloride; sodium hydroxide;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; toluene;
1.1: Wittig Reaction;
