N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

Base Information

Chemical Name:N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide
CAS No.:96886-64-5
Molecular Formula:C₄₄H₄₈N₅O₅P
Molecular Weight:757.869
Hs Code.:

N<sub>α</sub>-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

Synonyms:N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

Chemical Property:

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Technology Process of N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

There total 17 articles about N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 96886-64-5
N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / 4M aq. NaOH, 1M aq. NaHCO₃ / 18 h / Ambient temperature

2: 83 percent / DCCI, ammonium salt of hydroxybenzotriazole / CH₂Cl₂ / Ambient temperature

3: 96 percent / H₂ / 10percent Pd/C / dimethylformamide / 18 h / Ambient temperature

4: CH₂Cl₂; dimethylformamide / 0.67 h / 0 °C

5: 90 percent / 10M methanolic HCl / methanol; CDCl₃ / 1.67 h / 0 °C

6: N-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.5 h / 0 °C

7: 90 percent / 10M methanolic HCl / methanol / 1.58 h / 0 °C

8: N-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.5 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; ammonium salt of hydroxybenzotriazole; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; chloroform-d1; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 96886-64-5
N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / DCCI, ammonium salt of hydroxybenzotriazole / CH₂Cl₂ / Ambient temperature

2: 96 percent / H₂ / 10percent Pd/C / dimethylformamide / 18 h / Ambient temperature

3: CH₂Cl₂; dimethylformamide / 0.67 h / 0 °C

4: 90 percent / 10M methanolic HCl / methanol; CDCl₃ / 1.67 h / 0 °C

5: N-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.5 h / 0 °C

6: 90 percent / 10M methanolic HCl / methanol / 1.58 h / 0 °C

7: N-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.5 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; ammonium salt of hydroxybenzotriazole; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; chloroform-d1; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5241-56-5,17324-88-8,53562-23-5,4801-80-3
benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate

: 96886-64-5
N_α-diphenylphosphinoylphenylalanylphenylalanylvalylphenylalanine amide

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / H₂ / 10percent Pd/C / dimethylformamide / 18 h / Ambient temperature

2: CH₂Cl₂; dimethylformamide / 0.67 h / 0 °C

3: 90 percent / 10M methanolic HCl / methanol; CDCl₃ / 1.67 h / 0 °C

4: N-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.5 h / 0 °C

5: 90 percent / 10M methanolic HCl / methanol / 1.58 h / 0 °C

6: N-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.5 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; chloroform-d1; dichloromethane; N,N-dimethyl-formamide;