(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Base Information

Chemical Name:(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine
CAS No.:144735-40-0
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

Synonyms:(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Suppliers and Price of (2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

There total 15 articles about (2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-39-0
benzyl bromide

: 153108-84-0
(2S)-N-(cyanomethyl)-2-<(R)-1-(dimethoxymethyl)-1-hydroxyethyl>pyrrolidine

: 144735-40-0
(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Guidance literature:: With potassium hydride; In tetrahydrofuran; for 2h; Heating;

Reference yield:

: 144735-39-7
(2S)-2-<(R)-1-(dimethoxymethyl)-1-hydroxyethyl>pyrrolidine

: 144735-40-0
(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: methanol

2: ZnBr₂

3: TBAF

4: NaH, TBAI

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; zinc dibromide; In methanol;
DOI:10.1021/ja961640y

Reference yield:

: 91550-08-2
(S)-2-acetylpyrrolidine-1-carboxylic acid tert-butyl ester

: 144735-40-0
(2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂ / Ambient temperature

2: 1.) BuLi / 1.) hexane, THF, -30 deg C to -20 deg C, 1.5 h, 2.) hexane, THF, -78 deg C, 30 min

3: 68 percent / Hg(ClO₄)2*3H₂O / CHCl₃ / 3 h / Ambient temperature

4: 89 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

5: 91 percent / KH / tetrahydrofuran / 2 h / Heating

With n-butyllithium; mercury(II) perchlorate; potassium hydride; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;