Technology Process of (S)-4-(2,5-Dimethoxy-3,4,6-trimethylphenyl)-2-hydroxybutansaeure
There total 2 articles about (S)-4-(2,5-Dimethoxy-3,4,6-trimethylphenyl)-2-hydroxybutansaeure which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; triethylamine;
bis(cyclooctadiene)rhodium(I) perchlorate; (R)-1-[(S)-1',2-bis(diphenylphosphino)ferrocenyl]ethanol;
In
tetrahydrofuran;
for 44h;
under 11250.9 Torr;
Ambient temperature;
DOI:10.1002/hlca.19900730431
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4.9 g / KOH / methanol / 5 h / Heating
2: 93 percent / Et3N, H2 / Rh<(cod)2>ClO4, (R)-(R)-BPPFOH / tetrahydrofuran / 44 h / 11250.9 Torr / Ambient temperature
With
potassium hydroxide; hydrogen; triethylamine;
bis(cyclooctadiene)rhodium(I) perchlorate; (R)-1-[(S)-1',2-bis(diphenylphosphino)ferrocenyl]ethanol;
In
tetrahydrofuran; methanol;
DOI:10.1002/hlca.19900730431
- Guidance literature:
-
Multi-step reaction with 8 steps
1: pentane / Heating
2: 1) LDA
3: LiAlH4 / diethyl ether
4: 95 percent / pyridine / CH2Cl2 / a) 0 deg C, 1h, b) r.t., 16h
5: 105 mg / 1,5N KOH/EtOH / 0.17 h / Ambient temperature
6: CuBr*Me2S / diethyl ether / Ambient temperature; or Cu(I)-pentin-1-ide
7: 480 mg / Ce(NH4)2(NO3)6 / acetonitrile; H2O / 1 h / Ambient temperature
8: 1) H2, 2) conc. HCl / 1) 10percent Pd/C / 1) MeOH, 760 Torr, 2) 50 deg C, 2h
With
pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; copper(I) bromide dimethylsulfide complex; ethanol; hydrogen; lithium diisopropyl amide;
palladium on activated charcoal;
In
diethyl ether; dichloromethane; water; acetonitrile; pentane;
DOI:10.1002/hlca.19900730431
