2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Base Information

Chemical Name:2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
CAS No.:1575612-05-3
Molecular Formula:C₁₂H₁₂FN₃*ClH
Molecular Weight:253.707
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

There total 3 articles about 2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

: 928319-28-2
8-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyrazine

: 1575612-05-3
2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;
DOI:10.1021/jm4016284

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1575612-05-3
2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; bromine / 12.33 h / 15 - 50 °C

2: 12 h / 35 °C

3: palladium on activated charcoal; hydrogen / methanol / 12 h / 50 °C / 2585.81 Torr

With palladium on activated charcoal; hydrogen; bromine; acetic acid; In methanol;

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1575612-05-3
2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 35 °C

2: palladium on activated charcoal; hydrogen / methanol / 12 h / 50 °C / 2585.81 Torr

With palladium on activated charcoal; hydrogen; In methanol;